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J Appl Toxicol 35:581592

Mitigation strategies include strict sun protection during treatment, using moderate rather than aggressive microneedling depths, incorporating niacinamide which helps prevent PIH, considering patch testing before full-face treatment, and being prepared to pause treatment if significant PIH develops

Here's the nuance, though

Glutathione for Skin: Dosing Protocols and Safety Considerations Standard IV protocols for skin brightening use 6001200mg per session, administered once or twice weekly for 812 weeks

10.1007/BF00298361 28 FrauchigerD

Even dissolved in water, the physics of a handheld oral 'spray' delivery system are obvious