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The majority of this evidence comes from in vitro fibroblast cultures and animal work

New England Journal of Medicine (2022) 4

This is the mechanism that makes TB-500 relevant to injuries that involve slow or stalled healing: when the local repair response has exhausted its resources, TB-500 recruits fresh cells from the surrounding tissue and circulatory system into the damage zone

In Vitro Copper tripeptide (1 nM

A synthetic version of the FOXO4 protein is FOXO4-DRI, which was developed to be identical to a fragment of the endogenously available FOXO4 protein, except for the alteration in its amino acid structure

The results have been consistently promising across multiple tissue types and organ systems, though large-scale human clinical trials remain limited