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Co-delivery systems combining GSH-depleting agents with IDO-1 inhibitors or STING agonists further elevate T-cell infiltration

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Moreover, POX activity can result in immediate oxidative changes in the cellular environment by simultaneously depleting intracellular proline and producing superoxide (O 2 ) [ 137 ]

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Therefore, they suggested that stimulation of autophagy and HIF-1 by COVID-19 may be a marker for AML patients, especially those with FLT3-ITD mutations