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COX-2 modulated lipid peroxidation and oxidative stress in TAA-induced chronic liver injury and erastin-induced hepatocyte ferroptosis Lipid peroxidation is pivotal for initiating ferroptosis, and polyunsaturated fatty acids are the most susceptible lipids in peroxidation, such as arachidonic acid (AA, C20:4), adrenic acid (AdA, C22:4), linoleic acid (Lin, C18:2), and C22:6

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PMID: 42100892 Eur J Pharmacol Capsaicin attenuates DSS-induced IBD by suppressing macrophage M1 polarization via inhibition of the TRAF1/NF-B pathway

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As a control, we tested the crosslinking of SPIN1 with probe 11 (Supplementary Fig