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The investigation of combination therapies, particularly those involving immune modulators and inhibitors of other fibrotic pathways, offers a promising direction for future research and clinical application

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For example, oxidative stress triggers dissociation of the Trx:ASK1 complex by oxidizing thioredoxin, resulting in the activation of ASK1 (Tobiume et al ., 2002)

At the terminal stage, tumor-associated neutrophils appeared to be largely depletion-resistant (Supplementary Fig

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