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however, the effectiveness of selenium, which is predominantly a constituent of enzymes, is not proportional to the dose

doi:10.2147/TCRM.S11325

To further elucidate its mechanism in asthma-related ferroptosis, we performed virtual docking screening combined with molecular dynamics simulations, which revealed that luteolin binds effectively to ALOX15 and maintains the protein in a relatively stable conformation, thereby potentially mitigating ferroptosis in asthma by inhibiting ALOX15

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Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH et al (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis