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64 BRIC is characterized by acute onset of recurrent bouts (at least two episodes) of cholestasis that present as jaundice and severe pruritus, with periods of no symptoms for weeks to years, 65 and normal laboratory and histology findings during the intervening periods

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Besides their therapeutic benefits, long-term oral probiotics offer protection for healthy women as well ( By replenishing diminished Lactobacilli , probiotics can offer protective functions comparable to natural Lactobacilli

The incidence of cholesterol gallstones is dramatically increasing in parallel with the global epidemic of insulin resistance, type 2 diabetes, expansion of visceral adiposity due to overweight and obesity, and metabolic syndrome [20,21,22]