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Additionally, SKOR gating was also shown to depend on the external K + concentration so that the shift of the equilibrium potential for K + , E K , was followed by almost equal shift of the voltage dependence of the channel open probability (Gaymard et al., Reference Gaymard, Pilot, Lacombe, Bouchez, Bruneau, Boucherez, Michaux-Ferrire, Thibaud and Sentenac1998

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These findings suggest that CB-839 may induce alternative mechanisms of mitochondrial SOX accumulation