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10.1016/s0928-4257(97)89474-0 120 SikiricP.SeiwerthS.GrabarevicZ.RucmanR.PetekM.JagicV.et al (1997a)

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Nonetheless, as mentioned above, the hypovascular nature of the connective tissues makes it challenging to utilize the fundamental building blocks of the bloodstream

That's also where diabetic peripheral neuropathy adds another layer of complexity impaired circulation and nerve signaling make the already-limited healing environment in foot tissue even harder to overcome without targeted support