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The fact that the best-fitting model was quadratic rather than strictly linear is itself informative: it suggests that pushing the dose to 6.0 mg did not buy additional histologic benefit and may have shifted the tolerability balance, exactly the kind of nuance a dose-finding trial exists to surface

Molecular docking was performed using Maestro by Schrdinger suite to investigate the binding modes of sertraline, fluoxetine, and citalopram to MRP1 and MRP7 (Figure 3)