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By precisely regulating metal valence states and spatial distribution, CFS NPs overcome the randomness limitation of traditional metal ion interference therapy (MIIT), significantly enhance tumor oxidative damage, and achieve efficient tumor suppression

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Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization