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Dysfunction of the microbiota leads to decreased BA activity, reducing unconjugated BA and secondary BA production, weakening FXR activity, and exacerbating cirrhosis through various pathways: (1) In hepatocytes, FXR interacts with nuclear receptors such as peroxisome proliferator-activated receptors (PPAR)- and liver X receptor (LXR) to form heterodimers, regulating downstream target gene expression

Selank Peptides Selank is a synthetic neuropeptide commonly incorporated into peptide therapy regimens for stress support, mood balance, and nervous system regulation

Regarding thyroid function, immunological modulation, and redox equilibrium, its essential to keep Se consumption within the physiological range, as both low and high levels might lead to adverse clinical effects [17]

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[DOI] [PubMed] [Google Scholar] 72.Spiller HA, Winter ML, Klein-Schwartz W, Bangh SA