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Acknowledgements This work was supported by the National Key Research and Development Program of China (2024YFC2418800, 2022YFC2504300), the National Natural Science Foundation of China (92468107, 82422045, 82102593, and 82402814), the Capitals Funds for Health Improvement and Research Program by Beijing Municipal Health Commission (2024-2-5052), the Beijing Natural Science Foundation (L256032, 7262117), PLA General Hospital Youth Independent Innovation Science Fund project (22QNFC041), and the China Postdoctoral Science Foundation (XJ2021051)

MLKL, mixed lineage kinase domain-like pseudokinase

C57BL/6 mice were injected in the right flank with 1.0 10 6 LLC cells

S1G and S1H)

Experimental protocols vary widely, with differences in CP dosing schedules, timing, and duration of protective agent treatment, and choice of endpoints (Kim and You 2021)

However, there is currently no consensus on the optimal reference intake levels of selenium, primarily due to the insufficient epidemiological data regarding the dose-response link between selenium and certain health effects