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Endothelial ion transporters, including the Na-H and Na-K-Cl cotransporter, become dysregulated upon neuronal injury, resulting in an imbalance of ionic gradients and cytotoxic edema that contribute to secondary neuronal damage (Pinheiro et al., 2016)

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The majority of both classical trials (82/116, 71.3%) and interdisciplinary trials (194/271, 72.4%) reported only one primary outcome measure (Table 2)

While there may not be a direct cause-and-effect relationship, an unexplained or persistent Vitamin B12 deficiency warrants further exploration to rule out a serious condition, even a hidden malignancy