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The hypoxic microenvironment promotes angiogenesis within fibroid tissue, yet the resulting blood vessels exhibit abnormally thin walls

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158,159,160 Recent research shows that hepatocytes release cholesterol and C-X-C motif chemokine ligand 1 (CXCL1), drawing neutrophils from the bone marrow to the injured liver, where they subsequently secrete HGF to enhance hepatocyte proliferation and support liver regeneration

This phenomenon further supports an increase in cancer cell biosynthetic programs and maintenance of redox balance during uncontrolled proliferation 1