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Although CD8 + T cells may be more susceptible to ammonia under certain tumor microenvironments or immunosuppressive conditions, other immune cells (such as CD4 + T cells and macrophages)may also undergo cell death due to ammonia overload

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Further studies confirmed these results by demonstrating that resveratrol increased the expression of hepatic SIRT1, liver X receptor (LXR), and farnesoid X receptor (FXR) both with and without exercise (70)

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10.1073/pnas.0510962103 Proc