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In an experimental study with the use of human thyroid follicles isolated from normal paranodular tissue, it was observed that a high iodide dose (10 3 M) caused marked inhibition of radioiodine accumulation and organification process, as well as it induced necrosis of thyrocytes and ultrastructural lesions such as apical blebbing, cytoplasmic fragments desquamation, endoplasmic reticulum vesiculation, and accumulation of lipofuscin in secondary lysosomes [174]

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Its core function is to neutralize free radicals and protect cells from oxidative damage

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GSH depletion and oxidative cell damage result from the formation of the opioidglutathione adduct interfering with ascorbic acid recycling and all other glutathione functions [37]

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