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According to this finding, acute exposure to AFB1 resulted in p53-induced oxidative damage, dysregulation of gluconeogenesis, and lipid metabolism, in turn, leading to hepatotoxicity of AFB1 (307)

Alternative methods maybe more sensitive and offer quantitative evaluation of liver histology

Treatment of TLS requires vigorous intravenous hydration (Mughal 2014

Newsome PN, Ambery P

A study of patients with pancreatic cancer and gastrointestinal tumors reported that during omega-3 supplementation prior to chemotherapy, patients gained an average of approximately 2.5 kilograms of body weight, which was maintained after chemotherapy was initiated ( 3.4 Anticancer mechanisms of phytosterols and alkaloids 3.4.1 Interference with cholesterol metabolism and tumor cell membrane structure Phytosterols such as -sitosterol are structurally similar to cholesterol and competitively interfere with cholesterol utilization by tumor cells (78)

Given that the SLC39A8 p.Ala391Thr (rs13107325) variant has been associated with more than 22 clinical conditions, an important question is how this single missense variant can cause such a wide range of pathologies 44