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This pathology was proposed to be due to a neurodevelopmental liability that results in a greater elimination of dendritic spine (pruning) during infancy and adolescence, but its molecular mechanisms are still unclear (Moyer et al., 2015)

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There are several investigational agents in clinical trials utilizing this approach (Table 5)

[PubMed] [Google Scholar] 62.Cordero M.D., De Miguel M., Fernndez A.M.M., Lpez I.M.C., Maraver J.G., Cotn D., Izquierdo L.G., Bonal P., Campa F., Bullon P., et al

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HIV-associated antiretroviral toxic neuropathy (ATN): a review of recent advances in pathophysiology and treatment