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*Correspondence: Qiao Hong, [email protected] This article was submitted to Gastrointestinal Cancers: Colorectal Cancer, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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AOD-9604 trials did not demonstrate significant weight loss compared to placebo

Vitamin B12 deficiency can occur due to dietary restrictions (vegetarian or vegan diets), absorption issues (pernicious anemia or gut disorders like celiac disease or Crohns disease), age-related changes in elderly patients, or long-term use of certain medicines

These dosing conventions emerged from practitioner experience and extrapolation from preclinical models

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