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Clinical data has demonstrated that the effectiveness of combined SGLT2 inhibitor (SGLT2i) and GLP-1 receptor agonist (GLP1RA) therapy is partially additive in reducing HbA1c levels, body weight, and systolic blood pressure (70)

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Its principal physiological role is to transport long-chain fatty acids into the mitochondria the energy-producing structures within cells where they are broken down to generate energy

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