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This SCLC-specific feature of NE-non-NE plasticity may explain why, so far, the in vivo combination of BSO with Auranofin and Carboplatin has only achieved very limited efficacy in lung adenocarcinoma, which is not characterized by NE/non-NE plasticity 66

Primary carnitine deficiency is a genetic disorder of the cellular carnitine delivery system that typically manifests around the age of five with symptoms of cardiomyopathy, skeletal muscle weakness and hypoglycemia

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B12 injections are generally well-tolerated with mild injection site reactions, though rare hypersensitivity and hypokalaemia can occur, particularly when initiating treatment for severe deficiency

Tacrolimus 0.03% ointment is approved for use in children aged 2 years, and tacrolimus 0.1% ointment is approved for use in children aged 16 years