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In squamous cell carcinomas (SCC), saponin prevented UVB-induced cell carcinogenesis by enhancing NER gene expression and blocking NF-B activation (Sisto et al., 2012)

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Wood SM, Wiesener MS, Yeates KM, Okada N, Pugh CW, Maxwell PH, Ratcliffe PJ: Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 -subunit (HIF-1): Characterization of HIF-1-dependent and -independent hypoxia-inducible gene expression

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