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Abbreviations: SD, standard deviation

EdU staining Cells subjected to genetic treatments were seeded into 12-well plates at a density of 5 10 cells per well and cultured for 24 hours

Engagement of PD-1 by its ligands results in the recruitment of protein tyrosine phosphatases such as Src homology region 2 domain-containing phosphatase-2 (SHP2), which antagonizes downstream pathways required for metabolic reprogramming of activated T cells, including PI3K/Akt, Ras, ERK, Vav, and phospholipase C gamma (PLC) [106]

The resulting taurine deficiency can develop silently, over months or years, while the dog appears completely healthy

Williams DR, Brule H, Kelley SS, Skinner EA

[DOI] [PubMed] [Google Scholar] 8.Andrade R