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In summary, gut dysbiosis may contribute to PD pathogenesis through multiple mechanisms, including pathogendriven inflammation, metabolic alterations, immune activation, and enzymemediated proteotoxicity

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All WKY and SHR rats were placed in the locomotor boxes for two consecutive days to determine their baseline locomotor activities

Therefore, this complex, through the dual regulation of drug absorption and intestinal microecology by cyclodextrin, synergistically amplifies the inherent liver-protective and anti-inflammatory effects of silybin ( Silybin exerts anti-inflammatory and anti-fibrosis effects by activating Nrf2, inhibiting NF-B, and suppressing TGF-/Smad, and shows protective effects on normal cells and selective inhibition of tumor cells in intestinal experiments ( Table 4 )