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( Clostridium (primarily belonging to clusters IV and XIVa ) robustly increases Foxp3+ Treg numbers in the colonic lamina propria (LP) without affecting small intestinal Tregs

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NNMT is a cytosolic enzyme expressed in adipose tissue, liver, and skeletal muscle

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This process establishes a vicious cycle: mitochondrial damage leads to inflammasome activation, which in turn exacerbates mitochondrial damage (137, 138)

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Lee JH, Lee KH, Ryu JH, Kim MJ, Kim E, Lee SY, et al

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