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Repeatedly injecting the same spot causes lipohypertrophy firm lumps of thickened fat and scar tissue that absorb erratically, hurt less (so people keep using them, worsening the cycle), and can be slow to resolve

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Next, adult stem cells receive the call to action and mobilize to the injury site

Oral corticosteroids (prednisone) provide short-term anti-inflammatory benefit but have significant side effect profiles with repeated courses, including bone density loss, immune suppression, and metabolic disruption