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For example, LDloaded macrophages have been identified in human glioblastoma and were associated with an immunosuppressive state marked by increased CD39 and PD-L1 and reduced Major Histocompatibility Complex Class-II expression, suggesting that LD accumulation may support macrophage adaptation to the hostile tumor milieu while weakening anti-tumor immunity 148

Lewy bodies have also gained a lot of attention as to their specific distribution in neurons, and increases in their amount are consistent with both PD progression and neurodegeneration (Bethlem and Den Hartog Jager, 1984

Glucose is transported across the apical plasma membrane of intestinal epithelial cells by the sodium-glucose cotransporter ( SGLT , purple protein in the figure at right)

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doi: 10.1146/annurev-immunol-051116-052358, 34 DeepaS