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The formation of new blood vessels is often insufficient to provide adequate oxygen to the synovium, leading to a decrease in local microenvironmental oxygen tension and the formation of a hypoxic synovial microenvironment, which in turn affects angiogenesis, inflammatory responses, matrix degradation, cartilage erosion, energy metabolism disorders, and oxidative stress (126, 127)

AT: Investigation, Data curation, Writing review & editing

Retarded growth, life span, ultimate body size and age changes in the albino rat after feeding diets restricted in calories

Non-targeted metabolomic analysis of serum/plasma and biopsy samples identified altered metabolites with potential biomarker function to diagnose and stratify inflammatory diseases like systemic sclerosis, multiple sclerosis, atherosclerosis, inflammatory bowel disease (IBD) and sepsis [104,105,106,107, 156, 159, 160, 165, 167, 168, 171,172,173]

H., Longacre, M

In vivo Antitumor Efficacy in Murine Colorectal Cancer Model The in vivo therapeutic efficacy of CPBSN38L at the SN38-equivalent dose of 5 mg/kg was compared with that of CPT11, CPBSN38L, CL + US, PBSN38L + US, and PBS in an MC38 tumor model (Fig