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Growing evidence suggests that CRC cells exploit specific metabolic adaptation mechanisms to cope with the microenvironments of distant organs, thereby enhancing their invasiveness and metastatic colonization capacity

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Reconstitution sterility and refrigerated storage (28C) are the actual high-risk variables

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Interestingly, these changes to fibril deformation mechanics did not correspond to changes in fibril modulus and, thus, lend further support to the previous findings that AGE-derived mechanical changes are likely driven by changes at a larger scale, such as fiber-fiber sliding (Fessel et al ., 2014