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Description

Drofenine (30-1000 M) hydrochloride acts as a potent agonist of endogenous TRPV3 in HaCaT human keratinocytes, inducing calcium flux with an EC 50 of 605 M [4]

Beyond its role as an antioxidant, glutathione is essential for several other biological functions: Supporting the natural detoxification pathways in the liver

10.1016/j.nbd.2014.12.024 [DOI] [PMC free article] [PubMed] [Google Scholar] Zoroddu MA, Aaseth J, Crisponi G, Medici S, Peana M, & Nurchi VM (2019)

Blood 140:208221 Li Z, Yong H, Wang W, Gao Y, Wang P, Chen X, Lu J, Zheng J, Bai J (2023) GSK3326595 is a promising drug to prevent SARS-CoV-2 Omicron and other variants infection by inhibiting ACE2-R671 di-methylation

The crude compound was purified by flash chromatography (010% MeOH in DCM) to give the product as a pale yellow solid (360 mg, 75%) spectroscopically equivalent to previously reported examples