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Your liver removes fats and toxins from your body, so the healthier it is, the better it will work for you

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Severe deficiency in niacin can result in disease called pellagra, which can result in diarrhea, dermatitis, dementia, and possibly even death

PMID 11433365

Notably, p53-dependent activation of GLS-2 expression correlates with ROS, while elevated ROS levels lead to p53 stabilization and activation [89]