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doi: 10.1016/j.cell.2023.02.021 53 AlonsoRFlamentHLemoineSSedlikCBottassoEPguilletIet al

Hence, it was concluded that the manifestation of neuropathy, as well as some therapeutic responses in CIPN may be different from those observed in other peripheral neuropathies

Several investigational agents capable of inhibiting NLRP3 activation, such as tranilast, 354 dapansutrile (OLT1177, selective inhibitor), 354 and thiazolo-alkenyl sulfonylurea derivative 7, 355 are also being considered for COVID-CS treatment as reviewed by Freeman and Swartz

During niacin treatment, fasting glucose, insulin and HOMA1-IR (insulin resistance score based on blood glucose and insulin) increased in some individuals up to 1.9-fold after niacin dose of 500 mg, suggesting increased insulin resistance (Fig

These findings illustrate that OGT regulates de novo nucleotide synthesis by controlling the conversion of R5P to PRPP