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Illustrative non limitative examples of ALD therapies include: an antioxidant, an antioxidant targeted to mitochondria, a histone deacetylase inhibitor, an inhibitor of mitochondria transition pore opening, an anti-inflammatory drug, a PPAR agonist, a RXR agonist, asirtuin1 agonist, a hypolipidemic drug and an autophagy activator The term "antioxidants", as used herein, refer to substances that reduce the levels of reactive oxygen species, for instance preventing the formation of such reactive oxygen species or removing them before they produce any damage

doi: 10.1002/iub.2656 217 XuCYXuCXuYNDuSQDaiZHJinSQet al

Among the 14 identified human GLUT isoforms, GLUT1 to GLUT5 are the most extensively characterized, primarily transporting hexoses, notably D-glucose, while also facilitating the uptake of other hexoses, such as D-mannose and D-galactose, albeit with lower efficiency [48,49,50,51]

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Fifth, dealing with in-planta transformation issues in Agrobacterium -mediated (Maher et al., 2020) or nanoparticle-mediated ( Innovations in Cas9 offer precise editing of targeted genes and even simultaneous editing of multiple genes by multiplexing to accelerate breeding at reduced costs