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Phase 2 results indicate evenamide, a selective modulator of glutamate release, is associated with clinically important long-term efficacy when added to an antipsychotic in patients with treatment-resistant schizophrenia

doi: 10.1016/j.scienta.2018.01.060

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Zhang D, Tian X, Wang Y, Liu F, Zhang J, Wang H, et al

Samples were directly injected in an ESI-LTQ-XL Orbitrap Discovery instrument (Thermo Scientific, Bremen, Germany)

High levels of glucocorticoids synergize with excitatory amino acids, such as glutamate, to exacerbate excitotoxic damage a process linked to impaired glucose uptake and reduced energy metabolism in neurons (133)