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Results SIRT3 suppresses HSC response to classic trained immunity, acute inflammation and tissue functional decline To determine whether SIRT3 regulates HSC response to classic trained immunity induction, we crossed Cre-inducible Sirt3 -overexpressing mice with Mx1-Cre mice to generate mice that overexpress SIRT3 in the hematopoietic system (Mx1-T3) (Extended Data Fig

What matters is T3-related physiologyof which symptoms are the most sensitive indicator

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5.2 The guts role in mediating sleep and redox balance during aging The gastrointestinal tract has long been studied within the context of aging and exhibits multiple hallmarks of physiological decline, including altered microbial colonization, elevated low-grade inflammation, compromised barrier integrity, and reduced absorptive capacity

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