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Description

In vitamin B12 deficiency, the enzymes methionine synthase (in the homocysteine pathway) and methylmalonyl-CoA mutase (in the MMA pathway) are impaired because they depend on B12

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Bloodbrain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

Most vegans who use fortified foods or a daily supplement maintain normal B12 levels without ever needing an injection

Researchers utilize this mechanism to explore downstream effects on SIRT1 activation, which is a critical regulator of mitochondrial biogenesis, fat oxidation, and glucose metabolism