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The synthesis of GSH proceeds via two ATP-dependent enzymatic steps: Formation of -glutamylcysteine from glutamate and cysteine, which is followed by formation of GSH from -glutamylcysteine and glycine

To enhance their clinical potential, nanozyme-based catalytic systems are currently being optimized through formulation advancements and preclinical studies assessing their biocompatibility, anti-oxidant activity, antibacterial efficacy, and tissue repair capabilities, ensuring their safety and clinical applicability

The fluorescence readout of the sensors was recorded using the following excitation and emission bands: Peredox, NAPstar4.3 and NAPstarC: TS: Ex = 400 5 nm, Em = 520 5 nm

Interestingly, only first-trimester trophoblasts but not term trophoblasts respond to this stimulation (53)

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