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doi: 10.3389/fcell.2021.641449 Received 14 December 2020 Accepted 04 March 2021 Published 22 March 2021 Volume 9 - 2021 Edited by Marzia Di Donato, University of Campania Luigi Vanvitelli, Italy Reviewed by Leena Hilakivi-Clarke, Georgetown University, United States

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For researchers designing multi-point sampling protocols, understanding this timing enables optimal placement of blood or tissue sampling intervals to capture peak responses accurately

1 Institute of Biochemistry, Charit University Medicine Berlin, Berlin, Germany 2 Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Shatin, Hong Kong 3 Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong 4 Neuro-Degeneration and -Development and Repair, Institute of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong Embryo development relies on the complex interplay of the basic cellular processes including proliferation, differentiation, and apoptotic cell death

Dysregulated ROS signaling alters transcription factors and kinase pathways