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In the past 10 years, ferroptosis, an iron-dependent form of regulated cell death, has become increasingly recognized as an important process that mediates the pathogenesis and progression of numerous cardiovascular diseases, including atherosclerosis, drug-induced heart failure, myocardial ischaemiareperfusion injury, sepsis-induced cardiomyopathy, arrhythmia and diabetic cardiomyopathy

This, combined with the reduction of Lactic Acid accumulation in muscles, can extend exercise capacity before fatigue

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751 Furthermore, there are few researches reported on these screened natural compounds, and further research is needed to test their activity

Leptin suppresses microRNA-122 promoter activity by phosphorylation of foxO1 in hepatic stellate cell contributing to leptin promotion of mouse liver fibrosis