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difficile toxins in humans and in preclinical model, and changes to the ENS and extrinsic innervation contribute to intestinal inflammation, damage and secretory diarrhoea

LaccID activity is specific to the mammalian cell surface In mammalian cells, LacAnc100 is active at the cell surface but fusions targeted to the cytosol, mitochondria or endoplasmic reticulum (ER) lumen are inactive (Supplementary Fig

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doi: 10.1016/j.molcel.2021.08.027 11 Abu-FarhaMThanarajTAQaddoumiMGHashemAAbubakerJAl-MullaF

Headache, dysautonomia, and panic disorder have all been documented as neuropsychiatric manifestations of MCAS