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These include upregulating the Bax/Bcl-2 ratio in the mitochondria, 357 inducing HIF-1 degradation, 358 and involving with NF-B pathway 359 (Fig

By working on distinct substrate proteins, DUBs play a role in several biological processes, including cell proliferation, differentiation, and apoptosis

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Three-step paclitaxel-based therapy in patients with resectable esophageal carcinoma