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The aging process is marked by a gradual yet progressive decline in the functional capacity of multiple organs, impairing their ability to sustain baseline tissue homeostasis and adequately respond to physiological demands under stress ( 3.5 Chemotherapy-induced renal injury 3.5.1 Cisplatin-induced nephrotoxicity Cisplatin (CP) is a prominent chemotherapeutic agent utilized in the treatment of solid tumors ( 3.5.2 Methotrexate-induced renal injury Methotrexate (MTX), a potent anti-metabolite and folate antagonist, is administered at elevated doses for the treatment of various cancers, while lower doses are utilized for managing non-malignant conditions ( 3.5.3 Doxorubicin-induced renal intoxication Doxorubicin (DOX), a chemotherapeutic agent classified as an anthracycline, is a highly effective therapeutic used in the management of various hematological cancers and solid tumors ( 2 O 2 ), while concurrently reducing catalase (CAT) activity in the kidneys

Clinics are also trying to navigate changing guidance while still operating responsibly and ethically

Biochim Biophys Acta Mol Cell Biol Lipids 1866:158821

Headaches or dizziness can also occur, along with achy muscles or a general feeling of unease as your cells begin their repair work

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