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Future directions include nanoparticle systems bearing dual targeting (e.g., neutrophil receptor + adipose microenvironment ligand) and ROSresponsive release of antiNET agents timed to metabolic stress windows (e.g., postovulation, insulin surge)

doi: 10.3390/biom13081217 25 NakaiKYonedaKKubotaY

2019;8:e38

Other explored approaches are incrementing the channel dimensions (Gomez et al., 2014), and microfluidic channel parallelization (Shepherd et al., 2021)

For example, oxidative damage to normal cell during radiation therapy or chemotherapy will lead complication like inflammation, fibrosis, or the development of secondary cancers [91, 92]

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