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Function of the GSTP1-G6PD-SRC complex as a metabolic signalosome Our work implies that GSTP1 plays a dominant role linking G6PD and SRC to form a signalosome that provides a basis, under metabolic stresses, for robust cancer cell proliferation upon lactic acid signaling, which could regulate many aspects of cellular metabolism

Lockman PR, Mittapalli RK, Taskar KS, Rudraraju V, Gril B, Bohn KA, Adkins CE, Roberts A, Thorsheim HR, Gaasch JA, Huang S, Palmieri D, Steeg PS, Smith QR

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