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Consequently, the IL-23/Th17 axis has emerged as one of the premier therapeutic targets (e.g., IL-23p19 inhibitors) (Samarani et al., 2020)

Entacapone also exhibited anti-ferroptosis activity to alleviate IRI-induced renal damage and pathological changes in mice and erastin- or RLS3-induced lipid peroxidation and iron accumulation

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Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis

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At the joint microenvironment level, analyses of synovial fluid and cartilage tissue samples from OA patients, as well as studies in surgically induced such as the DMM model or chemically induced animal OA models, consistently observe clear iron metabolism abnormalities and significant iron accumulation locally in affected joints