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This therapy-induced PSMA overexpression establishes a self-amplifying targeting cyclethe mechanism that potentiates Psa-ARs selective tumor accumulation through PSMA-mediated endocytosis, creating a positive feedback loop between target engagement and drug delivery efficiency

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Additionally, the APOL1 gene may interact with other genes to cause kidney disease

increases the expression of Claudin-1, ZO-1 and Occludin

This is why it's used in wound care and topical skincare products, and why researchers study it for connective tissue repair