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More specifically, macrophages contribute to this metabolic foray by shifting metabolism between M1 or M2 states, altering concentrations of metals, and rewiring glycolysis and the tricarboxylic acid cycle to control bacterial pathogens [1012]

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Hence, miRNAs are one of the material bases for constructing central-peripheral inflammatory networks, creating critical communication pathways between central and peripheral inflammatory states ( Exosomes primarily consist of miRNAs, a highly representative type of nucleic acids

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