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SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts

2.2 Lactate shuttle Lactate, the terminal glycolytic metabolite, functions as a versatile molecular shuttleintracellularly, intercellularly, and systemicallymodulating cellular bioenergetics and redox equilibrium while accumulating across tissues via circulatory transport ( The aforementioned glycolytic reprogramming drives profound lactate and proton accumulation

When that NNMT machine runs hot, especially in adipose tissue, it chews through SAM and eats into the raw material for NAD+

Antioxidant activity studied for free-radical and anti-inflammatory effects

These factors may compensate for the lack of peroxidase (Cramer et al., 1982)

On la trouve notamment dans le foie, les lgumineuses (haricots mungo, lentilles), les herbes aromatiques (basilic, romarin, thym, etc.), les pinards et certaines crales (quinoa, muesli)