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Our results also suggest that disrupting the communication between some neurons triggers the secretion of excess sulphated hormone, from ASJ, in a process dependent on SSU1 (Fig 3A)

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Similarly, CPUY192018, a potent small-molecule inhibitor of the Keap1-Nrf2 PPI, demonstrated cytoprotective effects in NCM460 colonic cells and a DSS-induced UC model by activating Nrf2 signaling (262)

Second, we supplemented worms with commercially available ceramides containing different lengths of acyl chains and found that C22 ceramide (the ceramide containing BA, d18:1/22:0) and C24 ceramide (d18:1/24:0) restored the activity of gst-4p ::GFP in sptl-1 RNAi-treated worms (Fig

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